|
KMID : 0043320070300080955
|
|
Archives of Pharmacal Research
2007 Volume.30 No. 8 p.955 ~ p.961
|
|
|
Synthesis and Evaluation of Hydroquinone Derivatives as Inhibitors of Isocitrate Lyase
|
|
Yang Hyeong-Cheol
Yu Ji-Su
Oh Ki-Bong
Shin Dong-Sun
Cho Won-Jea
Shin Jong-Heon
Kim Sang-Hee
|
|
|
Abstract
|
|
|
|
Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against ICL of C. albicans. The preliminary structure-activity relationships and the minimal structural requirements for potency were established through structural modifications.
|
|
|
KEYWORD
|
|
|
Isocitrate lyase, Inhibitor, Hydroquinone, Halisulfate, C. albicans
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|